ion channels are naturally occurring pores through the proteins that regulate the passage of ions and thus maintain the concentration of ions inside and outside the cell. the ion channels control many physiological functions and they can show selectivity for a specific ion. ion channels are mostly observed in nerve cells and muscle cells. the influx of ions into cells can be regulated by a gate...

This paper investigates the electroosmotic micromixing of non-Newtonian fluid in a microchannel with wall-mounted obstacles and surface potential heterogeneity on obstacle surface. In numerical simulation, full model consisting Navier–Stokes equations Poisson–Nernst–Plank are solved for field, ion transport, electric power law is used to characterize rheological behavior aqueous solution. The m...

In order to calculate ion currents through solid-state nanopore transistors realistically, we propose a computational model based on the Poisson-Nernst-Plank equation. In the present model, we determine the surface charge density locally on the nanopore by imposing consistency between the ion distribution and the chemical reaction at the surface. The model can consider a non-uniform influence b...

Ion channels are naturally occurring pores through the proteins that regulate the passage of ions and thus maintain the concentration of ions inside and outside the cell. The ion channels control many physiological functions and they can show selectivity for a specific ion. Ion channels are mostly observed in nerve cells and muscle cells. The influx of ions into cells can be regulated by a gate...

Ion channels are naturally occurring pores through the proteins that regulate the passage of ions and thus maintain the concentration of ions inside and outside the cell. The ion channels control many physiological functions and they can show selectivity for a specific ion. Ion channels are mostly observed in nerve cells and muscle cells. The influx of ions into cells can be regulated by a gate...

The Poisson-Nernst-Planck (PNP) model is based on a mean-field approximation of ion interactions and continuum descriptions of concentration and electrostatic potential. It provides qualitative explanation and increasingly quantitative predictions of experimental measurements for the ion transport problems in many areas such as semiconductor devices, nanofluidic systems, and biological systems,...

In this study, a computational model was developed using commercial finite element analysis package COMSOL Multiphysics (Burlington, MA) to simulate the electrical double layer (EDL) structure and quantify the EDL capacitance for the first time. In the modeling the electrochemical process at an EDL structure was considered by solving the Poisson, Nernst-Plank and Butler-Volmer equations without...

Abstract In these notes, we have considered models of electrophysiology across several scales. The first was the membrane model. It assumes that action potential is similar whole cell membrane, and model represents as a function time alone. No spatial variable involved in pure models, so length scale does not make sense.

The fully open state of heterotypic gap junction channels formed by pairing cells expressing connexin 32 (Cx32) with those expressing connexin 26 (Cx26) rectifies in a way that cannot be predicted from the current-voltage (I-V) relation of either homotypic channel. Using a molecular genetic analysis, we demonstrate that charged amino acids positioned in the amino terminus (M1 and D2) and first ...